2,4-Dichlorobenzoyl chloride → 5-(2,4-Dichlorobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

HRID 66945ノート

反応式

HRID 66945 の反応式
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1.[Cl:11][C:12]1[CH:20]=[C:19]([Cl:21])[CH:18]=[CH:17][C:13]=1[C:14](Cl)=[O:15]>C1(C)C(C)=CC=CC=1>[Cl:11][C:12]1[CH:20]=[C:19]([Cl:21])[CH:18]=[CH:17][C:13]=1[C:14]([NH:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1)=[O:15]

参加物

4

反応物 2

HCID 666452,4-Dichlorobenzoyl chlorideHCID 6028483-(Trichloromethyl)-1,2,4-thiadiazol-5-amine

生成物 1

HCID 130415245-(2,4-Dichlorobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole収率 69.5%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 20.9 g (0.10 mole) 2,4-dichlorobenzoyl chloride was refluxed in 200 ml xylene for 20 hours. The reaction mixture was concentrated in vacuo and the resulting residue extracted with benzene. Addition of hexane resulted in precipitation of 13.6 g (69% yield) pure product; m.p. 136° C.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. extractionthe resulting residue extracted with benzene
  3. additionAddition of hexane

出典と根拠

ORDレコード
ord-5ed551a71a4646b6861ec463374c3df0
出典データセット
uspto-grants-1982_08
特許番号
US04343945

反応ノート

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