Benzylamine → Diethyl 3-benzylamino-2-pentenedioate

HRID 67043

反応式

HRID 67043 の反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][CH2:10][O:11][C:12]([CH2:14][C:15]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])=O)=[O:13]>C1(C)C=CC=CC=1>[CH2:10]([O:11][C:12](=[O:13])[CH:14]=[C:15]([NH:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:9]

参加物

4

反応物 2

HCID 7504BenzylamineHCID 66045Diethyl acetonedicarboxylate

生成物 1

HCID 70353029Diethyl 3-benzylamino-2-pentenedioate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Benzylamine (89.1 g, 0.83 moles) is added over 10 minutes to a suspension of 5 A powdered molecular sieves (270 g) and diethyl 1,3-acetonedicarboxylate 160 g) (0.79 moles) in 350 ml toluene (external cooling applied to control exotherm). The suspension is stirred at room temperature for 14-17 hours and then filtered to provide 2. The filter cake is washed with three portions of toluene. The combined filtrates may be used as is in the subsequent ketene reaction.

後処理

  1. filtrationfiltered
  2. customto provide 2
  3. washThe filter cake is washed with three portions of toluene
  4. customas is in the subsequent ketene reaction

出典と根拠

ORDレコード
ord-3018eb2cab444799be1cee45777264b6
出典データセット
uspto-grants-1982_08
特許番号
US04344885

関連ノート

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