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Triethylamine → 1-(3-chlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Bromo-3'-chloroacetophenone | HCID 38738 | — |
| 反応物 | 3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one hydrochloride | HCID 18321355 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1-(3-chlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine | HCID 12797992 | 50.4% |
反応手順
In this example, 2.67 g of 4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine mono-hydrochloride, 2.33 g of α-bromo-m-chloroacetophenone, 2.8 ml of triethylamine and 30 ml of methanol are mixed and stirred at room temperature overnight. Then, the white crystals deposited are separated by filtration, successively washed with methanol and water and dried to obtain 2.89 g of a crude product. The crude product is recrystallized from a mixed solvent of chloroform and ethanol to obtain 1.93 g of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04344948 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-1f54b4acf24a4bcbaa663e740ddf1acb |
| 出典メモ | uspto-grants-1982_08 |