4-Nitrophenyl chloroacetate → HCID 15754641、化合物

HRID 67101

反応式

HRID 67101 の反応式
[NH2:1][C:2]1[S:3][C:4]2[C:5](=[CH:7][C:8]3[N:9]=[C:10]([NH2:14])[S:11][C:12]=3[CH:13]=2)[N:6]=1.[Cl:15][CH2:16][C:17]([O:19]C1C=CC([N+]([O-])=O)=CC=1)=O>O1CCOCC1>[Cl:15][CH2:16][C:17]([NH:14][C:10]1[S:11][C:12]2[C:8](=[CH:7][C:5]3[N:6]=[C:2]([NH:1][C:17](=[O:19])[CH2:16][Cl:15])[S:3][C:4]=3[CH:13]=2)[N:9]=1)=[O:19]

参加物

4

反応物 2

HCID 949174-Nitrophenyl chloroacetateHCID 844005ST076754

生成物 1

HCID 15754641HCID 15754641、化合物収率 93%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture consisting of 222 mgm of 2,6-diamino-benzo[1,2-d:5,4-d']bisthiazole, 500 mgm of p-nitro-phenyl chloroacetate and 5 ml of dioxane were refluxed for 15 minutes. The reaction mixture was allowed to cool, and the crystalline substance which had separated out was filtered off, washed and dried. 350 mgm (93% of theory) of 2,6-bis-(chloroacetyl-amino)-benzo[1,2-d:5,4-d']bisthiazole, M.P. 330° C., were obtained.

後処理

  1. temperaturewere refluxed for 15 minutes
  2. temperatureto cool
  3. customthe crystalline substance which had separated out
  4. filtrationwas filtered off
  5. washwashed
  6. customdried

出典と根拠

ORDレコード
ord-d9a630a06f58499e841f82342f7220a8
出典データセット
uspto-grants-1982_08
特許番号
US04344946

関連ノート

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