Diethylamine → 2-(Diethylamino-acetylamino)6-amino-benzo[1,2-d:5,4-d']bisthiazole

HRID 67105

反応式

HRID 67105 の反応式
Cl[CH2:2][C:3]([NH:5][C:6]1[S:7][C:8]2[C:9](=[CH:11][C:12]3[N:13]=[C:14]([NH2:18])[S:15][C:16]=3[CH:17]=2)[N:10]=1)=[O:4].[CH2:19]([NH:21][CH2:22][CH3:23])[CH3:20]>O1CCOCC1>[CH2:19]([N:21]([N:5]([C:3](=[O:4])[CH3:2])[C:6]1[S:7][C:8]2[C:9](=[CH:11][C:12]3[N:13]=[C:14]([NH2:18])[S:15][C:16]=3[CH:17]=2)[N:10]=1)[CH2:22][CH3:23])[CH3:20]

参加物

4

反応物 2

HCID 8021DiethylamineHCID 205282012-Chloroacetylamino-6-amino-benzo[1,2-d:5,4-d']bisthiazole

生成物 1

HCID 867385292-(Diethylamino-acetylamino)6-amino-benzo[1,2-d:5,4-d']bisthiazole

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 0.5 gm of 2-(chloroacetyl-amino)-6-amino-benzo[1,2-d:5,4-d']bisthiazole, 0.7 gm of diethylamine and 3 ml of dioxane was refluxed for 2 hours. Then, the solvent was evaporated in vacuo, the residue was dissolved in ethyl acetate, and the solution was washed with water and dried over sodium sulfate. After evaporation of the solvent, 0.3 gm (60% of theory) of the title compound, M.P. 203°-205° C. (from ethanol/dimethylformamide) were obtained.

後処理

  1. temperaturewas refluxed for 2 hours
  2. customThen, the solvent was evaporated in vacuo
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. washthe solution was washed with water
  5. dry with materialdried over sodium sulfate
  6. customAfter evaporation of the solvent, 0.3 gm (60% of theory) of the title compound
  7. customM.P. 203°-205° C. (from ethanol/dimethylformamide) were obtained

出典と根拠

ORDレコード
ord-cce5813548c3422aa236ff55eaeacd1a
出典データセット
uspto-grants-1982_08
特許番号
US04344946

関連ノート

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