Calcium Carbonate → calcium 5-p-chlorobenzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate

HRID 67118

反応式

HRID 67118 の反応式
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([C:6]([C:8]2[N:12]3[CH2:13][CH2:14][CH:15]([C:16]([O-:18])=[O:17])[C:11]3=[CH:10][C:9]=2[Cl:19])=[O:7])=[CH:4][CH:3]=1.[K+].C(=O)([O-])[O-].[Ca+2:27].[Cl-].[NH4+].[Ca]>Cl.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[N:12]3[CH2:13][CH2:14][CH:15]([C:16]([O-:18])=[O:17])[C:11]3=[CH:10][C:9]=2[Cl:19])=[O:7])=[CH:20][CH:21]=1.[Ca+2:27].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[N:12]3[CH2:13][CH2:14][CH:15]([C:16]([O-:18])=[O:17])[C:11]3=[CH:10][C:9]=2[Cl:19])=[O:7])=[CH:20][CH:21]=1

参加物

7

反応物 4

HCID 10112Calcium Carbonate2 回HCID 25517Ammonium ChlorideHCID 5460341CalciumHCID 23675450potassium 5-p-chlorobenzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate2 回

生成物 1

HCID 20528128calcium 5-p-chlorobenzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 962Water溶媒

実験手順

To a solution of 175 mg of 5-p-chlorobenzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid in 5 ml of methanol is added 1 molar equivalent of potassium hydroxide, in the form of a 0.1 N solution, thus yielding a solution containing potassium 5-p-chlorobenzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate. A solution of 40 mg of calcium carbonate dissolved in the minimum amount of 1 N hydrochloric acid necessary to effect solution of the calcium carbonate, is buffered with 100 mg of solid ammonium chloride, followed by the further addition of 5 ml of water. The thus obtained buffered calcium solution is then added to the solution of potassium 5-p-chlorobenzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate and the precipitate which forms is collected by filtration, washed with water and air dried to yield calcium 5-p-chlorobenzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate.

後処理

  1. customThe thus obtained
  2. filtrationthe precipitate which forms is collected by filtration
  3. washwashed with water and air
  4. customdried

出典と根拠

ORDレコード
ord-8296646771b3453dbf167669a052129d
出典データセット
uspto-grants-1982_08
特許番号
US04344943

関連ノート

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