Methylamine → 4-(Methylamino)-3-nitrophenyl phenyl ketone

HRID 67150

反応式

HRID 67150 の反応式
Cl[C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:4][C:3]=1[N+:16]([O-:18])=[O:17].[CH3:19][NH2:20].S1(CCCC1)(=O)=O>CO>[CH3:19][NH:20][C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:4][C:3]=1[N+:16]([O-:18])=[O:17]

参加物

5

反応物 3

HCID 6329MethylamineHCID 31347SulfolaneHCID 417434-Chloro-3-nitrobenzophenone

生成物 1

HCID 966894-(Methylamino)-3-nitrophenyl phenyl ketone

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

11 g of 4-chloro-3-nitro-benzophenone, 20 g of methylamine, 153.4 g of methanol and 27.5 g of sulpholane are warmed to 125° for 15 hours in a closed vessel. The reaction solution is evaporated to dryness, the residue is boiled thoroughly with 400 ml of 2 N hydrochloric acid for 20 minutes and the precipitate is filtered off, washed with water and dissolved in methylene chloride. After drying over sodium sulphate and evaporating, 4-methylamino-3-nitro-benzophenone with a melting point of 198°-201° is obtained.

後処理

  1. customThe reaction solution is evaporated to dryness
  2. filtrationthe precipitate is filtered off
  3. washwashed with water
  4. dissolutiondissolved in methylene chloride
  5. dry with materialAfter drying over sodium sulphate
  6. customevaporating

出典と根拠

ORDレコード
ord-4fda088e904e42a7a0008e495677d659
出典データセット
uspto-grants-1982_08
特許番号
US04344957

関連ノート

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