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Acetic Acid → 4-Nitro-benzylidene-hydantoin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 4-Nitrobenzaldehyde | HCID 541 | — |
| 反応物 | Hydantoin | HCID 10006 | — |
| 反応物 | Ammonium Acetate | HCID 517165 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 4-Nitro-benzylidene-hydantoin | HCID 4685905 | 93.9% |
反応手順
A mixture of 100 grams (1.0 mole) of hydantoin, 151 grams (1.0 mole) of 4-nitrobenzaldehyde, 77 grams (1.0 mole) of ammonium acetate, 120 grams (2.0 moles) of acetic acid, and 200 ml of n-butanol were held for 3 hours at reflux temperature. After the cooling, there were obtained 219 grams of 5-(4'-nitrobenzylidene)-hydantoin, corresponding to 94% of the theory based on hydantoin. The product had a melting point of 253°-254° C. and homogeneous by thin layer chromatography.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04345072 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-7fefe04751574bbd82fd98bf15e2f617 |
| 出典メモ | uspto-grants-1982_08 |