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Sodium hydride → 4-(6-Chloro-3-pyridazinyloxy)-2,5-dimethylbenzeneamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3,6-Dichloropyridazine | HCID 67331 | — |
| 反応物 | 4-Amino-2,5-dimethylphenol | HCID 76544 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 4-(6-Chloro-3-pyridazinyloxy)-2,5-dimethylbenzeneamine | HCID 13050844 | — |
反応手順
4.8 g of sodium hydride was added in portions to a stirred solution of 30 g of 3,6-dichloropyridazine and 27.4 g of 4-amino-2,5-dimethylphenol in 300 ml of dimethyl sulfoxide. The temperature of the mixture rose to 65° C. The mixture was then stirred for 18 hours at room temperature, poured over ice water and filtered. Recrystallization of the filter cake from methanol gave 4-(6-chloro-3-pyridazinyloxy)-2,5-dimethylbenzeneamine, as a brown solid (5A), mp: 138°-140° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04345076 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-d7f16098e6ce4f10a35106a753a04e7c |
| 出典メモ | uspto-grants-1982_08 |