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Triphenylphosphine → (3-(1,3-Dioxoisoindolin-2-yl)propyl)triphenylphosphonium bromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | N-3-Bromopropylphthalimide | HCID 21611 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | (3-(1,3-Dioxoisoindolin-2-yl)propyl)triphenylphosphonium bromide | HCID 22018487 | 46.1% |
反応手順
The 3-phthalimidopropyltriphenylphosphonium bromide was prepared as follows. To a solution of triphenylphosphine (24.5 g, Aldrich, U.S.A.) in toluene (200 mL) was added N-(3-bromopropyl)phthalimide (25 g, Aldrich, U.S.A.). The mixture was heated to reflux overnight. The white solid so formed was isolated by filtration and dried under vacuum to yield 3-phthalimidopropyltriphenylphosphonium bromide (22.8 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084154B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-e96b0f6e3a4f4f18982b5bc493f3a1d2 |
| 出典メモ | uspto-grants-2006_08 |