Epichlorohydrin → 2-Ethoxy-1-methylpyridinium fluoroborate

HRID 67179

反応式

HRID 67179 の反応式
C(C1OC1)Cl.B(F)(F)F.[CH3:10][CH2:11][O:12][CH2:13][CH3:14].[F:15][B-:16]([F:19])([F:18])[F:17].[CH2:20]([O+:22]([CH2:25][CH3:26])[CH2:23][CH3:24])[CH3:21].[CH3:27][N:28]1C=C[CH:31]=[CH:30][C:29]1=O>CCOCC.C(Cl)Cl>[F:15][B-:16]([F:19])([F:18])[F:17].[CH2:20]([O+:22]([CH2:25][CH3:26])[CH2:23][CH3:24])[CH3:21].[F:15][B-:16]([F:19])([F:18])[F:17].[CH2:11]([O:12][C:13]1[CH:14]=[CH:31][CH:30]=[CH:29][N+:28]=1[CH3:27])[CH3:10]

参加物

8

反応物 4

HCID 7835EpichlorohydrinHCID 8000Boron trifluoride etherateHCID 127551-Methyl-2(1H)-pyridinoneHCID 2723982Triethyloxonium tetrafluoroborate

生成物 2

HCID 2723982Triethyloxonium tetrafluoroborateHCID 130594562-Ethoxy-1-methylpyridinium fluoroborate収率 71%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒2 回HCID 6344Dichloromethane溶媒2 回

実験手順

Triethyloxonium fluoroborate is prepared from 3.70 g (0.040 mole) of epichlorohydrin in 14 ml of ether and 7.58 g (0.054 mole) of boron trifluoride etherate in 6 ml of ether. The resulting solid triethyloxonium tetrafluoroborate is dissolved in 20 ml of dry methylene chloride and treated under nitrogen with 4.36 g (0.040 mole) of 1-methyl-2-pyridone in 15 ml of methylene chloride. The reaction mixture is stirred under nitrogen at room temperature overnight (about 16 hours). The solvent is evaporated at room temperature, in vacuo and the quaternary salt obtained is recrystallized from methanol-ether (1:1) to give 8.0 g (71%) of 2-ethoxy-1-methylpyridinium fluoroborate, m.p. 58°-60° C.

後処理

  1. customThe solvent is evaporated at room temperature, in vacuo
  2. customthe quaternary salt obtained
  3. customis recrystallized from methanol-ether (1:1)

出典と根拠

ORDレコード
ord-184a5348c3a84a9f84afde24a9c1123e
出典データセット
uspto-grants-1982_08
特許番号
US04345083

関連ノート

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