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Hydrochloric Acid → 3-[3-(4-Methoxyphenyl)propyl]glutaric acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 反応物 | Cyanoacetic acid | HCID 9740 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-(4-Methoxyphenyl)butanal | HCID 10487555 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-[3-(4-Methoxyphenyl)propyl]glutaric acid | HCID 20528827 | — |
反応手順
4(4-Methoxyphenyl)butyraldehyde (5.34 g) is reacted with cyanoacetic acid (5.15 g) and sodium hydroxide (2.74 g) in a mixture of glyme (50 ml) and water (60 ml). The mixture is treated with hydrochloric acid and processed as described in Example 2A to afford the title compound (2.1 g) which on crystallization from ethyl acetate-chloroform-hexane had a melting point of 71°-73° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04345096 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-10b05713b21542bd86cd938be251207c |
| 出典メモ | uspto-grants-1982_08 |