2-Bromo-1,2-diphenylethan-1-one → 2,3,5,6,7,8-Hexahydro-2,3-diphenylthiazolo[3,2-a][1,3]diazepin-3-ol hydrobromide

HRID 67230

反応式

HRID 67230 の反応式
[NH:1]1[CH2:7][CH2:6][CH2:5][CH2:4][NH:3][C:2]1=[S:8].[Br:9][CH:10]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12]>CC(C)=O>[BrH:9].[C:19]1([CH:10]2[S:8][C:2]3=[N:3][CH2:4][CH2:5][CH2:6][CH2:7][N:1]3[C:11]2([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[OH:12])[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

参加物

4

反応物 2

HCID 1026302-Bromo-1,2-diphenylethan-1-oneHCID 7365891,3-Diazepane-2-thione

生成物 1

HCID 205282882,3,5,6,7,8-Hexahydro-2,3-diphenylthiazolo[3,2-a][1,3]diazepin-3-ol hydrobromide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A 2.6 g. portion of hexahydro-2H-1,3-diazepin-2-thione is dissolved in 150 ml. of acetone and clarified. A 5.5 g. portion of 2-bromo-2-phenylacetophenone is added and the solution is refluxed for one hour and then stirred at room temperature for 16 hours. The solid is collected, washed with acetone and dried in vacuo at 60° C., giving 6.5 g. of the desired product, m.p. 195°-197° C. (dec.).

後処理

  1. temperaturethe solution is refluxed for one hour
  2. customThe solid is collected
  3. washwashed with acetone
  4. customdried in vacuo at 60° C.
  5. customgiving 6.5 g

出典と根拠

ORDレコード
ord-a3c634d5fec74401a80367e4f62dcb78
出典データセット
uspto-grants-1982_08
特許番号
US04344954

関連ノート

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