Sarcosine → 1-Methyl-1-(hydroxycarbonylmethyl)-3-(3,4-dichlorophenyl) urea

関与物質

反応手順

To a stirred solution of 89 g. of sarcosine in 300 ml. of water containing 60 g. of sodium hydroxide were added portion-wise over thirty minutes 188 g. of 3,4-dichlorophenyl isocyanate. The reaction mixture was stirred for thirty minutes following the addition, and then was filtered. The filtrate was acidified with concentrated hydrochloric acid, whereupon a white solid precipitated. The solid was collected by filtration and air dried to give 1-methyl-1-(hydroxycarbonylmethyl)-3-(3,4-dichlorophenyl) urea. M.P. 103°-105° C.

情報源と証拠