関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sarcosine | HCID 1088 | — |
| 反応物 | 5-methyl-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione | HCID 10487522 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 3,4-dihydro-4,6-dimethyl-2H-1,4-benzodiazepine-2,5(1H)-dione | HCID 21708975 | — |
反応手順
A mixture of 14.0 g (79 mmol) of 6-methylisatoic acid anhydride, 7.04 g (79 mmol) of sarcosine and 80 ml of dimethyl sulphoxide is stirred at 110° C. for 3 hours. The red coloured solution is evaporated in a high vacuum. The residue is treated with 80 ml of ethanol, the product crystallising out. There is obtained 3,4-dihydro-4,6-dimethyl-2H-1,4-benzodiazepine-2,5(1H)-dione of melting point 200°-202° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04346031 |
|---|
| 出典データセット | uspto-grants-1982_08 |
|---|
| ORD ID | ord-3182e92f9292405e8150e0d2d9c7d3f1 |
|---|
| 出典メモ | uspto-grants-1982_08 |
|---|
