化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → 2,3,4,9-tetrahydro-1H-beta-carbolin-6-ol hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Serotonin Hydrochloride | HCID 160436 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2,3,4,9-tetrahydro-1H-beta-carbolin-6-ol hydrochloride | HCID 22018498 | — |
反応手順
To a solution of 3-(2-amino-ethyl)-1H-indol-5-ol hydrochloride (10.0 g) in 450 mL of absolute ethanol was added 1.6 g of paraformaldehyde and 5.4 mL of glacial acetic acid. The mixture was heated to reflux for 1.5 h then allowed to cool to rt. The white precipitate so formed was collected by filtration and dried under vacuum to yield 5.9 g of 2,3,4,9-tetrahydro-1H-β-carbolin-6-ol hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084154B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-94519c87f60641e69754c5d68bb615e7 |
| 出典メモ | uspto-grants-2006_08 |