反応式
[ClH:1].[NH2:2][CH2:3][CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:14])[CH:12]=2)[NH:7][CH:6]=1.C=O.[C:17](O)(=O)C>C(O)C>[ClH:1].[CH2:17]1[C:6]2[NH:7][C:8]3[C:13](=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=3)[C:5]=2[CH2:4][CH2:3][NH:2]1参加物
5
実験手順
To a solution of 3-(2-amino-ethyl)-1H-indol-5-ol hydrochloride (10.0 g) in 450 mL of absolute ethanol was added 1.6 g of paraformaldehyde and 5.4 mL of glacial acetic acid. The mixture was heated to reflux for 1.5 h then allowed to cool to rt. The white precipitate so formed was collected by filtration and dried under vacuum to yield 5.9 g of 2,3,4,9-tetrahydro-1H-β-carbolin-6-ol hydrochloride.
後処理
- temperatureThe mixture was heated
- temperatureto reflux for 1.5 h
- customThe white precipitate so formed
- filtrationwas collected by filtration
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-94519c87f60641e69754c5d68bb615e7
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07084154B2
関連ノート
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