関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Acetaldehyde | HCID 177 | — |
| 反応物 | Serotonin Hydrochloride | HCID 160436 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 6-Hydroxy-1,2,3,4-tetrahydro-beta-carboline | HCID 159959 | — |
反応手順
Acetic acid was added dropwise to a solution of 3-(2-amino-ethyl)-1H-indol-5-ol hydrochloride (200 mg) in 7 mL of methanol until the pH=4. Acetaldehyde (0.2 mL) was added and the mixture was heated at 75° C. in a sealed tube for 1 h. The tube was cooled to rt and unsealed. The solvent was evaporated yielding 160 mg of 2,3,4,9-tetrahydro-1H-β-carbolin-6-ol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07084154B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-ec54e13d81204fff901de7e6692aa8ad |
|---|
| 出典メモ | uspto-grants-2006_08 |
|---|
