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Acetic Acid → 1-trifluoromethyl-2,3,4,9-tetrahydro-1H-beta-carbolin-6-ol hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Ethanol, 1-ethoxy-2,2,2-trifluoro- | HCID 9897 | — |
| 反応物 | Serotonin Hydrochloride | HCID 160436 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-trifluoromethyl-2,3,4,9-tetrahydro-1H-beta-carbolin-6-ol hydrochloride | HCID 22018500 | — |
反応手順
A mixture of 3-(2-amino-ethyl)-1H-indol-5-ol hydrochloride (0.5 g), trifluoroacetaldehyde ethyl hemiacetal (0.35 mL), acetic acid (0.32 mL) and ethanol (22.5 mL) was heated at reflux for 16 h. The solvent and excess reagents were evaporated to dryness under vacuum. The residue was washed with diethyl ether to afford 1-trifluoromethyl-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol hydrochloride (0.5 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084154B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-600460d8babf4f8aadae29babece78a3 |
| 出典メモ | uspto-grants-2006_08 |