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Acetic Acid → (5-methoxy-4-methyl-1H-indol-3-ylmethyl)dimethylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Dimethylamine | HCID 674 | — |
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | 5-Methoxy-4-methylindole | HCID 3296242 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | (5-methoxy-4-methyl-1H-indol-3-ylmethyl)dimethylamine | HCID 22018474 | — |
反応手順
Acetic acid (0.39 mL) and dimethylamine (0.85 mL of a 40% aqueous solution) were added to a suspension of paraformaldehyde (0.21 g) in 25 mL ethanol. The mixture was heated to reflux until it was clear. The solution was cooled to rt and a solution of 5-methoxy-4-methyl-indole (1.0 g) in 25 mL of ethanol was added. The reaction was heated to reflux for 3 h. The volatiles were removed in vacuo to yield (5-methoxy-4-methyl-1H-indol-3-ylmethyl)-dimethylamine (1.0 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084154B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-cb0d67a099774221b16872d3e7d1a7ba |
| 出典メモ | uspto-grants-2006_08 |