反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6](NCC)=[CH:5][CH:4]=1.[CH2:12]([N:14](CC)[CH2:15][CH3:16])[CH3:13].C(OC(=O)C)(=[O:21])C>ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:13][CH2:12][NH:14][C:15](=[O:21])[CH3:16])=[CH:7][CH:8]=1参加物
5
実験手順
To a mixture of (4-methoxy-phenyl)-ethylamine (10 g, Aldrich, U.S.A.) and triethylamine (10.1 mL) in dichloromethane (200 mL) was added acetic anhydride (7.4 g). The mixture was stirred at rt for 3 h and was washed successively with hydrochloric acid (1 M, 100 mL), 10% aqueous potassium carbonate (100 mL) and brine (100 mL). The dichloromethane layer was dried over sodium sulfate and filtered. The filtrate was evaporated to afford N-[2-(4-methoxy-phenyl)-ethyl]-acetamide (13.0 g).
後処理
- washwas washed successively with hydrochloric acid (1 M, 100 mL), 10% aqueous potassium carbonate (100 mL) and brine (100 mL)
- dry with materialThe dichloromethane layer was dried over sodium sulfate
- filtrationfiltered
- customThe filtrate was evaporated
出典と根拠
- ORDレコード
- ord-71c59c4825cc4dd98d2a6241a5eac55b
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07084154B2
関連ノート
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