2-Chloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylideneacetic Acid → 2-Chloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylacetic Acid

HRID 67640

反応式

HRID 67640 の反応式
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[C:6](=[CH:15][C:16]([OH:18])=[O:17])[C:7]3[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=3[CH2:9][CH2:10][C:4]=2[CH:3]=1>C(O)C.[Na].[Hg]>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[CH:6]([CH2:15][C:16]([OH:18])=[O:17])[C:7]3[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=3[CH2:9][CH2:10][C:4]=2[CH:3]=1

参加物

4

反応物 1

HCID 538262432-Chloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylideneacetic Acid

生成物 1

HCID 205274972-Chloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylacetic Acid

試薬・触媒・溶媒 2

HCID 9837419Sodium amalgam触媒HCID 702Ethanol溶媒

実験手順

A solution of 2-chloro-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-ylideneacetic acid (23.5 g, described in Example 1) in ethanol (100 ml, hot) is added to 5% sodium amalgam (100 g). The mixture is stirred at 60°-70° C. for 3 hr and decanted. The solution is evaporated of half its original volume, acidified with conc. hydrochloric acid and extracted with chloroform. The organic extract is dried and evaporated. The residue is crystallized from diethyl ether-hexane to give the title compound as crystals, mp 142°-146° C.

後処理

  1. customdecanted
  2. customThe solution is evaporated of half its original volume
  3. extractionextracted with chloroform
  4. extractionThe organic extract
  5. customis dried
  6. customevaporated
  7. customThe residue is crystallized from diethyl ether-hexane

出典と根拠

ORDレコード
ord-c37440869afb46ca9a86a45406a02ba3
出典データセット
uspto-grants-1982_08
特許番号
US04346090

関連ノート

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