Hydrochloric Acid → 5-Isothiazolecarboxylic acid, 3-(3-(trifluoromethyl)phenyl)-

反応式

[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]([C:9]2[CH:13]=[C:12]([C:14]([O:16]C)=[O:15])[S:11][N:10]=2)[CH:6]=[CH:7][CH:8]=1.[OH-].[K+].Cl.FC(F)(F)C1C=C(C2C=C(C([O-])=O)SN=2)C=CC=1>>[F:19][C:2]([F:1])([F:18])[C:3]1[CH:4]=[C:5]([C:9]2[CH:13]=[C:12]([C:14]([OH:16])=[O:15])[S:11][N:10]=2)[CH:6]=[CH:7][CH:8]=1

参加物

反応物 4

HCID 313Hydrochloric Acid

HCID 14797Potassium Hydroxide

HCID 13073224Methyl 3-(3-trifluoromethylphenyl)-5-isothiazolecarboxylate

HCID 867385453-(3-Trifluoromethylphenyl)-5-isothiazolecarboxylate

生成物 1

HCID 30679245-Isothiazolecarboxylic acid, 3-(3-(trifluoromethyl)phenyl)-収率 85%

実験手順

A solution of 1.6 g. of methyl 3-(3-trifluoromethylphenyl)-5-isothiazolecarboxylate in 30 ml. of 95% alcohol containing 1.0 g. of potassium hydroxide was heated at reflux for one hour. The reaction mixture then was added to 50 g. of ice, and the aqueous solution was acidified by the addition of 12 N aqueous hydrochloric acid. The product which precipitated was collected by filtration and crystallized from toluene and hexane to provide 1.3 g. of 3-(3-trifluoromethylphenyl)-5-isothiazolecarboxylate acid. Yield 85%. M.P. 162.5°-164° C.