N-(2-Hydroxyethyl)ethylenediamine → 4-oleoyloxyethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one
反応式
[OH:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][NH2:7].C(O[C:11](=[O:16])[CH2:12][C:13]([CH3:15])=O)C.[C:17](O)(=[O:35])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]/[CH:25]=[CH:26]\[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>>[C:17]([O:1][CH2:2][CH2:3][N:4]1[C:11](=[O:16])[CH2:12][C:13]([CH3:15])=[N:7][CH2:6][CH2:5]1)(=[O:35])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]/[CH:25]=[CH:26]\[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]参加物
4
実験手順
Into an apparatus similar to that in Example 1, were charged 104.2 g (1 mole) of N-hydroxyethylethylenediamine and 130.1 g (1 mole) of ethylacetoacetate. At 150° to 160° C., 18 g of water and 46 g of ethanol were distilled off. Then, after addition of 282.5 g (1 mole) of oleic acid, the esterification was effected at 210° to 215° C. to distil off 18 g of water and to obtain 4-oleoyloxyethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one.
後処理
- distillationAt 150° to 160° C., 18 g of water and 46 g of ethanol were distilled off