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3-Chlorobenzoic Acid → Thionyl Chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chlorobenzoic Acid | HCID 447 | — |
| 反応物 | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Benzoyl chloride, 3-chloro- | HCID 69252 | — |
| 生成物 | Thionyl Chloride | HCID 24386 | — |
| 生成物 | Oxazole, 2-(3-chlorophenyl)-4,5-dihydro-4,4-dimethyl- | HCID 10798476 | — |
反応手順
2-(3-Chlorophenyl)-4,4-dimethyl-2-oxazoline was prepared from 3-chlorobenzoic acid by reaction with thionyl chloride to give 3-chlorobenzoylchloride, reaction of this acid chloride with 2-amino-2-methylpropanol to give the amide and cyclization of the amide with thionyl chloride followed by neutralization with dilute sodium hydroxide to give 2-(3-chlorophenyl)-4,4-dimethyl-2-oxazoline.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04347177 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-fc3e60aa365a45c59398a6faf9402290 |
| 出典メモ | uspto-grants-1982_08 |