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Cysteamine → 6-Methyl-3-pyridylmethyl-4-pyrimidone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cysteamine | HCID 6058 | — |
| 反応物 | 5-((Dimethylamino)methyl)-2-furanmethanol | HCID 84906 | — |
| 反応物 | 5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine | HCID 162203 | — |
| 反応物 | HCID 178510869 | HCID 178510869 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 6-Methyl-3-pyridylmethyl-4-pyrimidone | HCID 136187296 | — |
反応手順
5-Dimethylaminomethyl-2-furanmethanol can be converted into 2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamine by heating under reflux in acetic acid with cysteamine and can be further converted into various histamine H2 -antagonists for example, by reacting with a substituted pyrimidone to give 2-2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamino-5-(6-methyl-3-pyridylmethyl-4-pyrimidone by methods described in EP 3677.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04347191 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-3bde087f247843d19e16bfe9b8309d82 |
| 出典メモ | uspto-grants-1982_08 |