Ammonium Hydroxide → 2-Amino-3-chlorobenzoic acid

HRID 67895

反応式

HRID 67895 の反応式
S(S([O-])=O)([O-])=O.[Na+].[Na+].[Cl:9][C:10]1[C:11]([N+:19]([O-])=O)=[C:12]([CH:16]=[CH:17][CH:18]=1)[C:13]([OH:15])=[O:14].[OH-].[NH4+]>O>[Cl:9][C:10]1[C:11]([NH2:19])=[C:12]([CH:16]=[CH:17][CH:18]=1)[C:13]([OH:15])=[O:14]

参加物

5

反応物 3

HCID 14923Ammonium HydroxideHCID 209023-Chloro-2-nitrobenzoic acidHCID 24489Sodium Dithionite

生成物 1

HCID 808072-Amino-3-chlorobenzoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

Sodium dithionite (104.4 g, 0.6 m) in water (400 ml) was added in portions to a slurry of 3-chloro-2-nitrobenzoic acid (30 g, 0.15 m) in water (200 ml) containing concentrated ammonium hydroxide solution (10 ml). After stirring an additional 20 minutes the mixture was filtered, acidified to pH 3-4 with concentrated hydrochloric acid and filtered again. The filtrate was saturated with sodium chloride and extracted with ether. Drying and concentration of the extract gave a white powder which was combined with the precipitates above. The crude product was used without further purification.

後処理

  1. filtrationwas filtered
  2. filtrationfiltered again
  3. extractionextracted with ether
  4. customDrying
  5. customconcentration of the extract gave a white powder which
  6. customprecipitates above
  7. customThe crude product was used without further purification

出典と根拠

ORDレコード
ord-706f0b1f994f43288963165420bbb526
出典データセット
uspto-grants-1982_08
特許番号
US04347246

関連ノート

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