Acetic Anhydride → N-[1-(6-Chloro-2-pyridyl)-2-pyrazolin-3-yl]formamide

HRID 67904ノート

反応式

HRID 67904 の反応式
[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:12][CH2:11][C:10]([NH:13][C:14](=[O:16])C)=[N:9]2)[CH:5]=[CH:4][CH:3]=1.C(OC(=O)C)(=O)C>C(O)=O>[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:12][CH2:11][C:10]([NH:13][CH:14]=[O:16])=[N:9]2)[CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 13050983N-[1-(6-Chloro-2-pyridyl)-2-pyrazolin-3-yl]acetamide

生成物 1

HCID 13050984N-[1-(6-Chloro-2-pyridyl)-2-pyrazolin-3-yl]formamide

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

A mixture of 5.0 g. of 2-(3-amino-2-pyrazolin-1-yl)-6-chloropyridine (prepared as described in Example 3) and 25 ml. of a mixture of formic acid and acetic anhydride (Feiser and Feiser, Reagents for Organic Synthesis, Vol. 1, page 4) at room temperature gives an immediate yellow precipitate. The precipitate is collected by filtration then is recrystallized from acetone-hexane to give 3.05 g. of the product of the Example as off-white crystals, m.p. 190°-192° C.

後処理

  1. additionA mixture of 5.0 g
  2. customgives an immediate yellow precipitate
  3. filtrationThe precipitate is collected by filtration
  4. customthen is recrystallized from acetone-hexane
  5. customto give 3.05 g

出典と根拠

ORDレコード
ord-b3c9d641736e4e999de7ec8af81e9585
出典データセット
uspto-grants-1982_08
特許番号
US04347251

反応ノート

読み込み中…