Piperidine → HCID 2804025、化合物

HRID 6793ノート

反応式

HRID 6793 の反応式
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([C:13]#[C:14][CH2:15]Br)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([C:13]#[C:14][CH2:15][N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1

参加物

5

反応物 3

HCID 8082PiperidineHCID 11430Potassium CarbonateHCID 2779977HCID 2779977、化合物

生成物 1

HCID 2804025HCID 2804025、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 1-(3,5-bistrifluoromethylphenyl)-3-bromoprop-1-yne (2.53 g), piperidine (5 ml) and anhydrous potassium carbonate (5 g) in dry acetone (50 ml) was heated at reflux with stirring for 18 h. Removal of the solvent under reduced pressure and distillation of the residue under reduced pressure gave 2.26 g of an oil of boiling point 95° C./0.025 mm Hg.

後処理

  1. temperaturewas heated
  2. temperatureat reflux
  3. customRemoval of the solvent
  4. distillationunder reduced pressure and distillation of the residue under reduced pressure

出典と根拠

ORDレコード
ord-02f0b0daf7f34f13804f67028ba672a7
出典データセット
uspto-grants-2006_08
特許番号
US07084158B2

反応ノート

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