(2E)-3-(4-Chlorophenyl)acryloyl chloride → (2E)-3-(4-chlorophenyl)-N-(2-piperidin-1-ylquinolin-6-yl)prop-2-enamide hydrochloride

HRID 6798

反応式

HRID 6798 の反応式
[N:1]1([C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([NH2:17])[CH:13]=3)[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22](/[CH:25]=[CH:26]/[C:27](Cl)=[O:28])=[CH:21][CH:20]=1.N1C2C(=CC(N)=CC=2)C=CC=1N>CC(O)=O.CCOCC>[ClH:18].[Cl:18][C:19]1[CH:20]=[CH:21][C:22](/[CH:25]=[CH:26]/[C:27]([NH:17][C:12]2[CH:13]=[C:14]3[C:9](=[CH:10][CH:11]=2)[N:8]=[C:7]([N:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[CH:16]=[CH:15]3)=[O:28])=[CH:23][CH:24]=1

参加物

6

反応物 3

HCID 11252649(2E)-3-(4-Chlorophenyl)acryloyl chlorideHCID 22018948Quinoline-2,6-diamineHCID 220189742-Piperidin-1-ylquinolin-6-amine

生成物 1

HCID 22018962(2E)-3-(4-chlorophenyl)-N-(2-piperidin-1-ylquinolin-6-yl)prop-2-enamide hydrochloride

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 3283Diethyl Ether溶媒

実験手順

To a solution of the product of Step D (91 mg, 0.4 mmol) in 2 mL HOAc was added the product of Step E (64 mg, 0.32 mmol). The resulting mixture was stirred at r.t. for 3 h then diluted with 3 mL ether. The resulting mixture was filtered and the resulting solids were washed with ether. The solids were dried under vacuum to afford the product, MS: m/z 392 (MH+), as an off-white solid. Using the appropriate starting materials and following procedures similar to those described above for Example 1, the following compounds were prepared from the corresponding quinoline-2,6-diamine intermediates:

後処理

  1. filtrationThe resulting mixture was filtered
  2. washthe resulting solids were washed with ether
  3. customThe solids were dried under vacuum
  4. customto afford the product, MS

出典と根拠

ORDレコード
ord-7ea16d5540f64108a374fefb1059f324
出典データセット
uspto-grants-2006_08
特許番号
US07084156B2

関連ノート

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