Dimethylamine → 4-ethyl-N2,N2-dimethyl-6-nitroquinolin-2-amine

反応式

Cl[C:2]1[CH:11]=[C:10]([CH2:12][CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:14]([O-:16])=[O:15])[CH:8]=2)[N:3]=1.[CH3:17][NH:18][CH3:19].CO>>[CH2:12]([C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:14]([O-:16])=[O:15])[CH:8]=2)[N:3]=[C:2]([N:18]([CH3:19])[CH3:17])[CH:11]=1)[CH3:13]

参加物

反応物 3

HCID 674Dimethylamine

HCID 887Methanol

HCID 220189542-chloro-4-ethyl-6-nitroQuinoline

生成物 1

HCID 698237704-ethyl-N2,N2-dimethyl-6-nitroquinolin-2-amine

実験手順

The product was obtained from the product of Step B and a solution of 2N dimethyl-amine in methanol (5 mL, 25 mmol) according to the procedure of Example 1, Step C.

出典と根拠

ORDレコード: ord-1e08e61b53f5439a82e9262f353c1054
出典データセット: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07084156B2

反応ノート

読み込み中…