Sodium hydroxide methanol → 3-({2-[(4-Cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid

HRID 68188

反応式

HRID 68188 の反応式
C[O:2][C:3](=[O:35])[CH2:4][CH2:5][N:6]([C:13]([C:15]1[CH:34]=[CH:33][C:18]2[N:19]([CH3:32])[C:20]([CH2:22][NH:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][CH:25]=3)=[N:21][C:17]=2[CH:16]=1)=[O:14])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[OH-].[Na+].CO>>[C:30]([C:27]1[CH:28]=[CH:29][C:24]([NH:23][CH2:22][C:20]2[N:19]([CH3:32])[C:18]3[CH:33]=[CH:34][C:15]([C:13]([N:6]([C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=4)[CH2:5][CH2:4][C:3]([OH:35])=[O:2])=[O:14])=[CH:16][C:17]=3[N:21]=2)=[CH:25][CH:26]=1)#[N:31]

参加物

3

反応物 2

HCID 23721981Sodium hydroxide methanolHCID 580694223-({2-[(4-Cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid methyl ester

生成物 1

HCID 580694233-({2-[(4-Cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid

反応条件

温度
40 °C

実験手順

To a solution of the product of 1d (13.0 mmol) in 100 mL methanol sodium hydroxide (20.0 mmol) was added. The mixture was stirred for 2.5 hours at 40° C. and then evaporated to dryness. The remaining solid was stirred with 100 mL water and the pH was adjusted to about 6 with concentrated acetic acid. The precipitated product was isolated by filtration, washed with water and dried at 60° C.

後処理

  1. customevaporated to dryness
  2. stirringThe remaining solid was stirred with 100 mL water
  3. customThe precipitated product was isolated by filtration
  4. washwashed with water
  5. customdried at 60° C.

出典と根拠

ORDレコード
ord-09cd8271a9db459ea2226cfcb13be652
出典データセット
uspto-grants-2014_09
特許番号
US08821871B2

関連ノート

読み込み中…