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4,6-Dichloropyrido[3,4-d]pyrimidine → (6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(3-fluorobenzyloxy)-phenyl)-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,6-Dichloropyrido[3,4-d]pyrimidine | HCID 10821876 | — |
| 反応物 | 4-(3-Fluoro-benzyloxy)-phenylamine | HCID 16775314 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | (6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(3-fluorobenzyloxy)-phenyl)-amine | HCID 21952062 | — |
反応手順
4,6-Dichloro-pyrido[3,4-d]pyrimidine (1 g) and 4-(3-fluorobenzyloxy)aniline (1.08 g) in acetonitrile (70 ml) were reacted together as in Procedure A. The product was collected by filtration as a yellow solid (1.86 g); m/z 381 (M+1)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084147B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-8b3bea1d833140cf9b8c1582932f75e3 |
| 出典メモ | uspto-grants-2006_08 |