化工社化工社 化学情報印刷レポート · 研究参考用
1-Benzyl-4-(pyridin-3-yl)piperazine → 1-(Pyridin-3-yl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Benzyl-4-(pyridin-3-yl)piperazine | HCID 21815409 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1-(Pyridin-3-yl)piperazine | HCID 437234 | 62% |
反応手順
31.3 g 1-Benzyl-4-pyridin-3-yl-piperazin was hydrogenated at 5 bar on 4 g 10% palladium on charcoal in 300 mL methanol at 50° C. for 25 h. The reaction was filtered. The filtrate was evaporated and purified by chromatography on silica gel (dichlormethane/methanol/ammonia (9/1/0.1)). 12.5 g of the desired compound was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822464B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-fe990aa700d7442d94c6508d1f0b7864 |
| 出典メモ | uspto-grants-2014_09 |