反応式
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].CO>[N:16]1[CH:17]=[CH:18][CH:19]=[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:15]=1参加物
4
実験手順
31.3 g 1-Benzyl-4-pyridin-3-yl-piperazin was hydrogenated at 5 bar on 4 g 10% palladium on charcoal in 300 mL methanol at 50° C. for 25 h. The reaction was filtered. The filtrate was evaporated and purified by chromatography on silica gel (dichlormethane/methanol/ammonia (9/1/0.1)). 12.5 g of the desired compound was obtained.
後処理
- filtrationThe reaction was filtered
- customThe filtrate was evaporated
- custompurified by chromatography on silica gel (dichlormethane/methanol/ammonia (9/1/0.1))
出典と根拠
- ORDレコード
- ord-fe990aa700d7442d94c6508d1f0b7864
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08822464B2
関連ノート
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