化工社化工社 化学情報印刷レポート · 研究参考用
Water → 1,3-Propanedione, 1,3-bis(4-fluorophenyl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4'-Fluoroacetophenone | HCID 9828 | — |
| 反応物 | Methyl 4-fluorobenzoate | HCID 67878 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1,3-Propanedione, 1,3-bis(4-fluorophenyl)- | HCID 73896 | — |
反応手順
9.27 g KOtBu was added to 109 mg 18-Krone-6 and 5 mL 4-fluoracetophenone in 150 mL THF. After 30 min at RT 10.7 g 4-fluoro-benzoic acid methyl ester was added and stirred for 3 h at RT. The reaction was decomposed with water and filtered, the filtrate was concentrated and the residue was purified by chromatography on silica gel (cyclohexane/EE: 98:2). The solvent was removed and 3.9 g of the desired compound was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822464B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-70cfdcee53bf4b3191c40dab3dfbd6eb |
| 出典メモ | uspto-grants-2014_09 |