化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 1-Cyclohexyl-3-(4-fluoro-phenyl)-propane-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Cyclohexyl methyl ketone | HCID 13207 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Methyl 4-fluorobenzoate | HCID 67878 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-Cyclohexyl-3-(4-fluoro-phenyl)-propane-1,3-dione | HCID 86762668 | — |
反応手順
0.88 g 60% sodiumhydrid was added 1-cyclohexyl-ethanone in 60 mL THF and stirred for 30 min. Then, 3.25 g 4-fluoro-benzoic acid methyl ester and 200 mg 18-Krone-6 was added to the reaction. The reaction was refluxed 2 h and stirred over night at RT. The reaction was added to 100 mL 1N HCl and extracted with diethylether. The organic layer was concentrated and the residue was purified by chromatography on silica gel and 3 g of the desired compound was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822464B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-b343e2f0437e49488452de340c3fca77 |
| 出典メモ | uspto-grants-2014_09 |