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Potassium Carbonate → Tert-butyl 2-(2-bromo-4-formylphenoxy)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Bromo-4-hydroxybenzaldehyde | HCID 76308 | — |
| 反応物 | tert-Butyl bromoacetate | HCID 79177 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Tert-butyl 2-(2-bromo-4-formylphenoxy)acetate | HCID 17999215 | 951.9% |
反応手順
To a solution of 3-bromo-4-hydroxybenzaldehyde (100 g, 50 mol, 1 eq) in acetone (500 mL) was added potassium carbonate (135 g, 100 mmol, 2 eq) followed by t-butyl 2-bromoacetate (100 g, 50 mmol, 1 eq). After stirring at room temperature for 2 h, the acetone was removed in vacuo and the resultant residue was washed with water to give 150 g (89%) of t-butyl 2-(2-bromo-4-formylphenoxy)acetate (1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822467B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-53c9217a3475467587c1b302503c9848 |
| 出典メモ | uspto-grants-2014_09 |