Trifluoroacetic acid methylene chloride → HCID 46899330、化合物
反応式
C(O)(C(F)(F)F)=O.C(Cl)Cl.[C:11]([C:13]1[CH:14]=[C:15]([C:19]2[CH:33]=[C:32]([CH2:34][NH:35][S:36]([C:39]3[CH:44]=[CH:43][C:42]([F:45])=[CH:41][CH:40]=3)(=[O:38])=[O:37])[CH:31]=[CH:30][C:20]=2[O:21][CH2:22][C:23]([O:25]C(C)(C)C)=[O:24])[CH:16]=[CH:17][CH:18]=1)#[N:12]>>[C:11]([C:13]1[CH:14]=[C:15]([C:19]2[CH:33]=[C:32]([CH2:34][NH:35][S:36]([C:39]3[CH:40]=[CH:41][C:42]([F:45])=[CH:43][CH:44]=3)(=[O:38])=[O:37])[CH:31]=[CH:30][C:20]=2[O:21][CH2:22][C:23]([OH:25])=[O:24])[CH:16]=[CH:17][CH:18]=1)#[N:12]参加物
3
実験手順
To a solution of TFA/DCM (1:3, 6 mL) was added t-butyl 2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetate (8) (51 mg, 0.10 mmol, 1 eq) and the mixture was stirred at room temperature for 2 h. The organic solvent was removed in vacuo and the crude product was purified by reversed phase preparative HPLC to give 36 mg (82%) of 2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetic acid (Example 9).
後処理
- customThe organic solvent was removed in vacuo
- customthe crude product was purified by reversed phase preparative HPLC