3-(methylthio)-6-nitro-1-phenyl-1H-indazole → 3-(methylthio)-1-phenyl-1H-indazol-6-amine

HRID 68677ノート

反応式

HRID 68677 の反応式
[CH3:1][S:2][C:3]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-])=O)=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:4]=1>C(OCC)(=O)C.[C].[Pd]>[CH3:1][S:2][C:3]1[C:11]2[C:6](=[CH:7][C:8]([NH2:12])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:4]=1

参加物

4

反応物 1

HCID 674475223-(methylthio)-6-nitro-1-phenyl-1H-indazole

生成物 1

HCID 498399773-(methylthio)-1-phenyl-1H-indazol-6-amine

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

A 100-mL round-bottom flask was purged, flushed and maintained with a hydrogen atmosphere, then, was added a solution of 3-(methylthio)-6-nitro-1-phenyl-1H-indazole (3.5 g, 12.28 mmol, 1.00 equiv) in ethyl acetate (30 mL), Palladium carbon (2.2 g), bubbled with H2 (gas). The resulting solution was stirred for 48 min at room temperature. The solids were filtered out. The resulting mixture was concentrated under vacuum to yield 3-(methylthio)-1-phenyl-1H-indazol-6-amine as brown oil. MS: 256 (MH+)

後処理

  1. customA 100-mL round-bottom flask was purged
  2. customflushed
  3. temperaturemaintained with a hydrogen atmosphere
  4. custombubbled with H2 (gas)
  5. filtrationThe solids were filtered out
  6. concentrationThe resulting mixture was concentrated under vacuum

出典と根拠

ORDレコード
ord-6674f5b0ea9d4893ac7410c13786772c
出典データセット
uspto-grants-2014_09
特許番号
US08822447B2

反応ノート

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