Hydrogen chloride-ethyl acetate → 3-ethyl-1-phenyl-1H-indazol-6-amine hydrochloride

HRID 68694

反応式

HRID 68694 の反応式
[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][C:8]([NH2:12])=[CH:9][CH:10]=2)[N:5]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:4]=1)[CH3:2].[ClH:19].CCOC(C)=O>>[ClH:19].[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][C:8]([NH2:12])=[CH:9][CH:10]=2)[N:5]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:4]=1)[CH3:2]

参加物

3

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 67449230HCID 67449230、化合物

生成物 1

HCID 674492293-ethyl-1-phenyl-1H-indazol-6-amine hydrochloride

実験手順

Into a 100-mL round-bottom flask, was placed 3-ethyl-1-phenyl-1H-indazol-6-amine (190 mg, 0.80 mmol, 1.00 equiv), hydrogen chloride/EtOAc (30 mL). The resulting solution was stirred for 30 min at room temperature. The resulting mixture was concentrated under vacuum. The resulting mixture was washed with diethyl ether (1×50 mL). The solids were collected by filtration to yield 3-ethyl-1-phenyl-1H-indazol-6-amine hydrochloride as a white solid.

後処理

  1. customInto a 100-mL round-bottom flask, was placed
  2. concentrationThe resulting mixture was concentrated under vacuum
  3. washThe resulting mixture was washed with diethyl ether (1×50 mL)
  4. filtrationThe solids were collected by filtration

出典と根拠

ORDレコード
ord-a5b2251b160c4d5dbe2f6231a3d00f66
出典データセット
uspto-grants-2014_09
特許番号
US08822447B2

関連ノート

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