Sulfuric Acid → 5-Amino-3-methyl-1-phenyl-1H-pyrazole-4-carboxamide

HRID 68719

反応式

HRID 68719 の反応式
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([CH3:13])[C:3]=1[C:14]#[N:15].S(=O)(=O)(O)[OH:17]>>[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([CH3:13])[C:3]=1[C:14]([NH2:15])=[O:17]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 2198585-amino-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile

生成物 1

HCID 158367655-Amino-3-methyl-1-phenyl-1H-pyrazole-4-carboxamide

実験手順

Into a 100-mL 3-necked round-bottom flask, was placed sulfuric acid (90 mL). To the resulting mixture was then added 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile (30 g, 151.52 mmol, 1.00 equiv), in portions at 10° C. The resulting solution was stirred overnight at room temperature. The reaction was then quenched by the addition of water/ice (100 mL). The pH value of the solution was adjusted to about 8-9 with potassium carbonate (conc.). The solids were collected by filtration, to yield 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carboxamide as a white solid.

後処理

  1. customInto a 100-mL 3-necked round-bottom flask, was placed
  2. customat 10° C
  3. customThe reaction was then quenched by the addition of water/ice (100 mL)
  4. filtrationThe solids were collected by filtration

出典と根拠

ORDレコード
ord-e06e226395d14707bace6cb8ef042d9d
出典データセット
uspto-grants-2014_09
特許番号
US08822447B2

関連ノート

読み込み中…