Hydrochloric Acid → HCID 178437919、化合物

HRID 68731

反応式

HRID 68731 の反応式
[ClH:1].[CH2:2]([C:4]1[C:12]2[C:7](=[N:8][C:9]([CH:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)=[N:10][C:11]=2[OH:13])[N:6]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:5]=1)[CH3:3].C(OC([N:33]1[CH2:37][CH2:36][C:35](=O)[CH2:34]1)=O)(C)(C)C.Cl>>[ClH:1].[CH2:2]([C:4]1[C:12]2[C:7](=[N:8][C:9]([CH:14]3[CH2:15][CH2:16][N:17]([CH:35]4[CH2:36][CH2:37][NH:33][CH2:34]4)[CH2:18][CH2:19]3)=[N:10][C:11]=2[OH:13])[N:6]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:5]=1)[CH3:3]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 471360Tert-butyl 3-oxopyrrolidine-1-carboxylateHCID 178437922HCID 178437922、化合物

生成物 1

HCID 178437919HCID 178437919、化合物

実験手順

The title compound was prepared according to the procedure as described in Example 88 reacting via reductive amination 3-ethyl-1-phenyl-6-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-4-ol hydrochloride and 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester followed by de-protection of the adduct with HCl.

出典と根拠

ORDレコード
ord-c9034252dcdb4bc1bbd92a1cf36d3ebd
出典データセット
uspto-grants-2014_09
特許番号
US08822447B2

関連ノート

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