関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Bromopropanedial | HCID 74945 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | (4-Methyl-pyridin-2-yl)-thiourea | HCID 2760059 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(4-Methylpyridin-2-ylamino)-thiazole-5-carbaldehyde | HCID 22019084 | 80% |
反応手順
A mixture of (4-methylpyridin-2-yl)-thiourea (334 mg, 2 mmol), 2-bromomalonaldehyde (302 mg, 2 mmol) and sodium acetate (250 mg, 3.0 mmol) in acetic acid (5 mL) was stirred at 100° C. for 3 h. The mixture was cooled to RT and diluted with water and the precipitate formed was collected, washed with water and dried to afford 2-(4-methylpyridin-2-ylamino)-thiazole-5-carbaldehyde (350 mg, 80%). MS m/z 220 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07084160B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-2e1d32d3e8fb4e439de64c8c1b26c148 |
|---|
| 出典メモ | uspto-grants-2006_08 |
|---|
