Hydrochloric Acid → 4-Ethoxy-3-ethyl-1-phenyl-6-(4-piperazin-1-yl-phenyl)-1H-pyrazolo[3,4-b]pyridine

HRID 68745

反応式

HRID 68745 の反応式
C[CH:2]1[NH:7][CH:6](C)[CH2:5][N:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[N:20]=[C:19]4[N:21]([C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=5)[N:22]=[C:23]([CH2:24][CH3:25])[C:18]4=[C:17]([O:32][CH3:33])[CH:16]=3)=[CH:11][CH:10]=2)[CH2:3]1.[C:34](OC(N1CCNCC1)=O)(C)(C)C.Cl>>[CH2:33]([O:32][C:17]1[CH:16]=[C:15]([C:12]2[CH:13]=[CH:14][C:9]([N:4]3[CH2:3][CH2:2][NH:7][CH2:6][CH2:5]3)=[CH:10][CH:11]=2)[N:20]=[C:19]2[N:21]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[N:22]=[C:23]([CH2:24][CH3:25])[C:18]=12)[CH3:34]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 143452tert-Butyl piperazine-1-carboxylateHCID 584835716-[4-(3,5-dimethyl-piperazin-1-yl)-phenyl]-3-ethyl-4-methoxy-1-phenyl-1H-pyrazolo[3,4-b]pyridine

生成物 1

HCID 584836024-Ethoxy-3-ethyl-1-phenyl-6-(4-piperazin-1-yl-phenyl)-1H-pyrazolo[3,4-b]pyridine

実験手順

The title compound was prepared according to the procedure as described in Example 98 reacting 6-(4-bromo-phenyl)-3-ethyl-4-ethoxy-1-phenyl-1H-pyrazolo[3,4-b]pyridine (according to Example 98) and piperazine-1-carboxylic acid tert-butyl ester, followed by de-protection with HCl.

出典と根拠

ORDレコード
ord-66712ea6e8f24f619a307929e424cdc3
出典データセット
uspto-grants-2014_09
特許番号
US08822447B2

関連ノート

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