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5-amino-N-cyclopropyl-2,4-difluorobenzamide → N-Cyclopropyl-2,4-difluoro-5-{[2-(4-methyl-pyridin-2-ylamino)-thiazol-5-ylmethyl]-amino}-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-amino-N-cyclopropyl-2,4-difluorobenzamide | HCID 21966507 | — |
| 反応物 | 2-(4-Methylpyridin-2-ylamino)-thiazole-5-carbaldehyde | HCID 22019084 | — |
| 生成物 | N-Cyclopropyl-2,4-difluoro-5-{[2-(4-methyl-pyridin-2-ylamino)-thiazol-5-ylmethyl]-amino}-benzamide | HCID 22019101 | — |
反応手順
2-(4-Methylpyridin-2-ylamino)-thiazole-5-carbaldehyde was treated with 5-amino-N-cyclopropyl-2,4-difluorobenzamide (for preparation see Example 18) in a manner similar to Example 1 to afford the title compound. LC/MS; (M+H)+=416.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084160B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-137bd54ea5d047a4b72c7657d212dda8 |
| 出典メモ | uspto-grants-2006_08 |