化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → N-Cyclopropyl-3-fluoro-4-oxazol-5-yl-N-piperidin-4-yl-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | tert-Butyl 4-(cyclopropylamino)piperidine-1-carboxylate | HCID 2769591 | — |
| 反応物 | 3-Fluoro-4-oxazol-5-yl-benzoic acid | HCID 68290144 | — |
| 反応物 | 1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonitrile | HCID 86678210 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-Cyclopropyl-3-fluoro-4-oxazol-5-yl-N-piperidin-4-yl-benzamide | HCID 68290215 | — |
反応手順
The title compound is prepared from 4-cyclopropylamino-piperidine-1-carboxylic acid tert-butyl ester and 3-fluoro-4-oxazol-5-yl-benzoic acid following a procedure analogous to that described in Intermediate 1. The cleavage of the BOC group is accomplished by using trifluoroacetic acid in dichloromethane. LC (method 14): tR=0.98 min; Mass spectrum (ESI+): m/z=330 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822471B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-f1e437eebe564c5b95d16d602c980288 |
| 出典メモ | uspto-grants-2014_09 |