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N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide → 3-amino-N-cyclopropyl-4-fluorobenzene-1-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide | HCID 8469273 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-amino-N-cyclopropyl-4-fluorobenzene-1-sulfonamide | HCID 22019122 | 95.5% |
反応手順
The mixture of N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide (520 mg, 2 mmol) and Pd/C (10%, 100 mg) in EtOH was hydrogenated (1 atm) overnight. The mixture was filtered through a short pad of celite and concentrated in vacuo to afford N-cyclopropyl-4-fluoro-3-aminobenzenesulfonamide (440 mg, 95%) as an ivory solid. LC/MS; (M+H)+=231.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084160B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-742bd07a01d3417fa9f833046b9b7c41 |
| 出典メモ | uspto-grants-2006_08 |