N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide → 3-amino-N-cyclopropyl-4-fluorobenzene-1-sulfonamide

HRID 6883

反応式

HRID 6883 の反応式
[CH:1]1([NH:4][S:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[C:10]([N+:15]([O-])=O)[CH:9]=2)(=[O:7])=[O:6])[CH2:3][CH2:2]1>CCO.[Pd]>[CH:1]1([NH:4][S:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[C:10]([NH2:15])[CH:9]=2)(=[O:7])=[O:6])[CH2:3][CH2:2]1

参加物

4

反応物 1

HCID 8469273N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide

生成物 1

HCID 220191223-amino-N-cyclopropyl-4-fluorobenzene-1-sulfonamide収率 95.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The mixture of N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide (520 mg, 2 mmol) and Pd/C (10%, 100 mg) in EtOH was hydrogenated (1 atm) overnight. The mixture was filtered through a short pad of celite and concentrated in vacuo to afford N-cyclopropyl-4-fluoro-3-aminobenzenesulfonamide (440 mg, 95%) as an ivory solid. LC/MS; (M+H)+=231.

後処理

  1. custom(1 atm) overnight
  2. filtrationThe mixture was filtered through a short pad of celite
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-742bd07a01d3417fa9f833046b9b7c41
出典データセット
uspto-grants-2006_08
特許番号
US07084160B2

関連ノート

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