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2,5-Dichloropyridine → N-(5'-Chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,5-Dichloropyridine | HCID 27685 | — |
| 反応物 | N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride | HCID 68289930 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | N-(5'-Chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide | HCID 68351885 | — |
反応手順
The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride and 2,5-dichloro-pyridine following a procedure analogous to that described in Example 19 using N-methylpyrrolidinone as solvent. LC (method 16): tR=0.43 min; Mass spectrum (ESI+): m/z=423 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822471B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-aec1aa3938c14c4d9ff90b04f26816aa |
| 出典メモ | uspto-grants-2014_09 |